Nicotinamide adenine dinucleotide (NAD+) is a coenzyme found in all living cells that plays an essential role in metabolism. It is involved in processes such as energy production, DNA repair, and cell signaling. As a result, NAD+ has been the subject of much research in recent years, with some scientists claiming that it has the potential to extend lifespan and treat a range of diseases.
However, like any compound, NAD+ has potential negative side effects that should be taken into consideration. In this blog post, we will explore some of the negative side effects of NAD+.
- Flushing and nausea
One of the most common side effects of NAD+ supplementation is flushing. This is a temporary redness and warmth of the skin, often accompanied by a feeling of nausea. Flushing occurs because NAD+ can cause the blood vessels to dilate, leading to increased blood flow to the skin. This side effect is generally mild and will subside within a few minutes.
- Allergic reactions
In rare cases, NAD+ supplementation can cause allergic reactions. Symptoms of an allergic reaction can include itching, hives, and swelling of the face, lips, tongue, or throat. If you experience any of these symptoms after taking NAD+, you should seek medical attention immediately.
- Interference with chemotherapy
Some studies suggest that NAD+ may interfere with the effectiveness of chemotherapy drugs. This is because NAD+ is involved in DNA repair, which can help cancer cells repair themselves and resist chemotherapy. If you are undergoing chemotherapy, you should speak to your doctor before taking NAD+.
- Interference with other medications
NAD+ may also interfere with the effectiveness of other medications. For example, some studies suggest that NAD+ may interfere with the blood-thinning medication warfarin. If you are taking any medications, you should speak to your doctor before taking NAD+.
- Unknown long-term effects
While NAD+ has been extensively studied, its long-term effects are not yet known. As with any supplement or medication, there may be unknown side effects that emerge over time. It is important to weigh the potential benefits of NAD+ against the unknown long-term effects before taking it.

